Does creating an allergic reaction on your skin open up the pores enough to let bigger drug molecules in?

I'm talking about hives and inflammation.Does creating an allergic reaction on your skin open up the pores enough to let bigger drug molecules in?
no. the skin swells and squeezes the pores shut. try sweating. sweating opens the poers. so does alcohol pads. and hot water.Does creating an allergic reaction on your skin open up the pores enough to let bigger drug molecules in?
By George I think you've got it.